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CD273 (B7-DC) ELISA Kits

ELISA kits are commonly used to measure soluble biomarkers across a variety of research areas. ELISA kits for CD273 (B7-DC) are available for Human and Mouse which can be quantified in various samples, including plasma, serum, supernatant, cell lysate.

Invitrogen ELISA kits exist in...
ELISA kits are commonly used to measure soluble biomarkers across a variety of research areas. ELISA kits for CD273 (B7-DC) are available for Human and Mouse which can be quantified in various samples, including plasma, serum, supernatant, cell lysate.

Invitrogen ELISA kits exist in two formats: Uncoated and Coated....
ELISA kits are commonly used to measure soluble biomarkers across a variety of research areas. ELISA kits for CD273 (B7-DC) are available for Human and Mouse which can be quantified in various samples, including plasma, serum, supernatant, cell lysate.

Invitrogen ELISA kits exist in two formats: Uncoated and Coated. Uncoated ELISA kits include all the necessary reagents to coat your own plates and run your assay with maximum flexibility. Coated ELISA kits...
ELISA kits are commonly used to measure soluble biomarkers across a variety of research areas. ELISA kits for CD273 (B7-DC) are available for Human and Mouse which can be quantified in various samples, including plasma, serum, supernatant, cell lysate.

Invitrogen ELISA kits exist in two formats: Uncoated and Coated. Uncoated ELISA kits include all the necessary reagents to coat your own plates and run your assay with maximum flexibility. Coated ELISA kits are ready-to-use and quality tested for sensitivity, specificity, precision and lot-to-lot consistency.

Target Information

Programmed death-ligand 2 (PD-L2), or B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily that, along with programmed death-ligand 1 (PD-L1), acts as a ligand for programmed cell death protein 1 (PD-1). Though expressed primarily in dendritic cells, PD-L2 expression can be induced on a wide variety of immune and non-immune cells depending on the microenvironment. PD-L2 expression is particularly upregulated in the presence of Th2 cytokine, IL-4, as well as Th1 cytokines, TNF-alpha and IFN-gamma to a lesser degree. While generally expressed at lower levels compared to PD-L1, PD-L2 demonstrates a 2 to 6 times higher relative affinity to PD-1 than PD-L1. PD-1 and its ligands are referred to as inhibitory immune checkpoint molecules in that they provide useful negative feedback during physiological homeostasis. Ligation of PD-L2 or PD-L1 inhibits activation, proliferation, and cytokine secretion (e.g. IFN-gamma, IL-10) in T cells, ultimately dampening immune response. Conversely, studies have shown that PD-L2 can also stimulate T cell proliferation and cytokine production, even in PD-1-deficient T cells, suggesting additional receptors. Recent studies have concluded that PD-L2 also binds to a second receptor, repulsive guidance molecule b (RGMb), which was originally identified as a receptor for bone morphogenetic proteins (BMPs). RGMb is expressed in the central nervous system, as well as in macrophages, however, its role in immunity is only beginning to emerge. Interaction between PD-L2 and RGMb regulates the development of respiratory tolerance in the lung through BMP and/or neogenin signaling pathways. The naturally occurring human PD-L2 monomer consists of a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.

Synonyms

B7 dendritic cell molecule; B7DC; B7-DC; bA574F11.2; Btdc; Butyrophilin B7-DC; butyrophilin-like protein; CD273; F730015O22Rik; MGC124039; MGC124040; PD1 ligand 2; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; PDCD1L2; Pdcd1lg2; Pdl2; PD-L2; Programmed cell death 1 ligand 2; programmed death ligand 2

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Invitrogen
Human PD-L2 ELISA Kit
Invitrogen
Human PD-L2 ELISA Kit
Sensitivity 3.65 pg/mL
Assay Range 39-2,500 pg/mL
Sample Volume
Cell Lysate
10 µL
Plasma
10 µL
Serum
10 µL
Time To Result
3 hr 30 min
(1 hr 20 min hands-on)
Price
Special offer
Online exclusive
Online offer:
Cat # BMS2215
Invitrogen
Mouse PD-L2/B7-DC ELISA Kit
Invitrogen
Mouse PD-L2/B7-DC ELISA Kit
Sensitivity 1.9 ng/mL
Assay Range 1.9-400 ng/mL
Sample Volume
Serum
50 µL
Plasma
50 µL
Supernatant
50 µL
Time To Result
4 hr 45 min
(1 hr 20 min hands-on)
Price
Special offer
Online exclusive
Online offer:
Cat # EM64RB
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